高橋 賢

Tag: mechanobiology

Report: Space Biology research

This article is from a newsletter of “Integral Understanding of life-regulation mechanism from ‘SPACE’ (Living in Space)“, a Grant-in-Aid for Scientific Research on Innovative Areas funded by the Japan Society for the Promotion of Science, in which Ken Takahashi participated as a project member. Mechanosensing Mechanisms for Sensing Mechanical Stress Including Gravitational Changes Goal Bone…
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Promoting Mechanobiology

Ken Takahashi was inaugurated as Associate Editor of Mechanobiology Journal on Sunday September 22, 2019. The goal of the journal is to improve the understanding of mechanobiology and ultimately provide approaches to translate into therapeutic strategies and rectifying husbandry and agricultural problems. Ken contributed to hold 2nd International Symposium on Mechanobiology in 2014 as Secretary General, and…
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Unravel the mechanism of joint pain

The joint fluids of patients with osteoarthritis contain elevated levels of inflammatory cytokines. These cytokines induce the expression of proteases in cartilage cells, which will lead to progress of joint destruction. Dr. Ohtsuki found that mechanical strain attenuates inflammatory cytokine-induced expression of matrix-degrading enzymes, which was published in Experimental Cell Research journal. According to the…
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Peer review: effect of microgravity on the development of zebrafish heart

A space biology article, on which Ken Takahashi performed peer review, was published in Journal of Biomechanics. This article will give a clue to understand the effect of gravity on the development of cardiovascular system. Effect of Simulated Microgravity Induced PI3K-nos2b Signalling on Zebrafish Cardiovascular Plexus Network Formation Related: Reviewer certificate gallery * * *…
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Peer review: cell stretch systems for studies of cardiac mechano-signaling

A mechanobiology article, on which Ken Takahashi performed peer review, was published in Frontiers in Bioengineering and Biotechnology journal. This article will help understanding methodology used in mechanobiology study. Stretch in Focus: 2D in-planar cell stretch systems for studies of cardiac mechano-signaling Related: Reviewer certificate gallery ### Takahashi Lab at Okayama University uses principles of physiology,…
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How do heart cells sense they are stretched?

Heart cells sense that they are stretched when the heart is subjected to high blood pressure. But how? It is known that concentration of calcium ion in cardiomyocytes increases when they are stretched. Takahashi and co-workers found that a specific protein, L-type calcium channel, is the key to this calcium increase event using rat cardiomyocytes.…
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