高橋 賢

Video released: model for ischemic heart disease with human iPS cardiomyocytes

Video released: model for ischemic heart disease with human iPS cardiomyocytes

JoVE video - Ken Takahashi

Summary

  1. Dr. Ken Takahashi of Okayama University published a video article about the model of ischemic heart disease using human iPS heart cells.
  2. The method makes it easier than before to create a cardiac ischemia model.
  3. The use of this model will lead to the development of drugs for ischemic heart disease and the elucidation of the cause of myocardial infarction.

On May 5, Research Associate Professor Ken Takahashi of Okayama University published an article about the model of ischemic heart disease using cardiomyocytes differentiated from human iPS cells (Biochem Biophys Res Commun 2019, 520(3): 600-605). A video for this experimental method was released to the public today in Journal of Visualized Experiments.

The method of producing myocardial tissue from human iPS cells has been difficult because it requires advanced technology and a great deal of labor. The video article published today makes the method and the following induction of ischemic myocardial damage easy. The spread of this method may lead to the development of drugs for ischemic heart disease and the elucidation of the pathophysiology of myocardial infarction.

Research to develop models of human diseases from iPS cells is an area that is expected to develop further in the future.

I welcome the support from future scientists, current scientists, and general public.

Ken Takahashi

This study was supported by the Fund for the Promotion of Joint International Research (Fostering Joint International Research), 17KK0168.

Related: Filming for JoVE, the top video science journal

Related: Heart attack modeled with human stem cells

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Takahashi Lab at Okayama University uses principles of physiology, cellular and molecular biology, and biophysics. The purpose of the lab is to develop science and medicine by unveiling the mechanisms of diseases through collaborations with scientists, epidemiologists, and corporate alliances. The alliance includes Harvard University, Boston University, Tokyo University of Science, and PD Aerospace, Ltd.

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