高橋 賢

タグ: mechanobiology

レポート:宇宙生物学研究

宇宙の微小重力環境下では骨量減少や筋萎縮が起こりますが、骨や筋肉などの細胞がどのように重力を感知しているかはよくわかっていません。この研究の目的は、細胞が重力を感知するしくみを...
続きを読む

Promoting Mechanobiology

Ken Takahashi was inaugurated as Associate Editor of Mechanobiology Journal on Sunday September 22, 2019. The goal of the journal is to improve the understanding of mechanobiology and ultimately provide approaches to translate into therapeutic strategies and rectifying husbandry and agricultural problems. Ken contributed to hold 2nd International Symposium on Mechanobiology in 2014 as Secretary General, and published Dynamic Remodeling of the Heart and Blood Vessels in Mechanobiology: Exploitation for Medical Benefit (Wiley, ISBN:9781118966143) in 2017. * * * Takahashi Lab at Okayama University uses principles of physiology, cellular and molecular biology, and biophysics. The purpose of the lab is to develop science and medicine by unveiling the mechanisms of diseases through collaborations…
続きを読む

Unravel the mechanism of joint pain

The joint fluids of patients with osteoarthritis contain elevated levels of inflammatory cytokines. These cytokines induce the expression of proteases in cartilage cells, which will lead to progress of joint destruction. Dr. Ohtsuki found that mechanical strain attenuates inflammatory cytokine-induced expression of matrix-degrading enzymes, which was published in Experimental Cell Research journal. According to the article, cyclic mechanical strain attenuated expression of proteases such as ADAMTS4, ADAMTS9, and MMP-13 in chondrocytes. This effect is likely due to activation of a mechanosensitive protein TRPV1. TRPV1 can be a potential therapeutic target in treating osteoarthritis. Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. Exp Cell Res 2019;…
続きを読む

Peer review: effect of microgravity on the development of zebrafish heart

A space biology article, on which Ken Takahashi performed peer review, was published in Journal of Biomechanics. This article will give a clue to understand the effect of gravity on the development of cardiovascular system. Effect of Simulated Microgravity Induced PI3K-nos2b Signalling on Zebrafish Cardiovascular Plexus Network Formation Related: Reviewer certificate gallery * * * Takahashi Lab at Okayama University uses principles of physiology, cellular and molecular biology, and biophysics. The purpose of the lab is to develop science and medicine by unveiling the mechanisms of diseases through collaborations with scientists, epidemiologists, and corporate alliances. The alliance includes Harvard University, Boston University, Tokyo University of Science, and PD Aerospace, Ltd.

Peer review: cell stretch systems for studies of cardiac mechano-signaling

A mechanobiology article, on which Ken Takahashi performed peer review, was published in Frontiers in Bioengineering and Biotechnology journal. This article will help understanding methodology used in mechanobiology study. Stretch in Focus: 2D in-planar cell stretch systems for studies of cardiac mechano-signaling Related: Reviewer certificate gallery ### Takahashi Lab at Okayama University uses principles of physiology, cellular and molecular biology, and biophysics. The purpose of the lab is to develop science and medicine by unveiling the mechanisms of diseases through collaborations with scientists, epidemiologists, and corporate alliances. The alliance includes Harvard University, Boston University, Tokyo University of Science, and PD Aerospace, Ltd.

How do heart cells sense they are stretched?

Heart cells sense that they are stretched when the heart is subjected to high blood pressure. But how? It is known that concentration of calcium ion in cardiomyocytes increases when they are stretched. Takahashi and co-workers found that a specific protein, L-type calcium channel, is the key to this calcium increase event using rat cardiomyocytes. The article “L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2” was published in Cell Calcium journal. https://doi.org/10.1016/j.ceca.2019.02.008 As the L-type calcium channels are one of the fundamental components of cardiomyocytes involved in beating of the heart, every medical student learns about them. If you have high blood pressure, you might be taking…
続きを読む

jaJapanese