タグ: cardiology

岡山大学の高橋賢研究准教授は5月5日、ヒトiPS細胞から分化した心筋細胞を用いて虚血性心疾患の病態モデルを発表しました(Biochem Biophys Res Commun 2019, 520(3): 600-605)。この実験方法の動画が本日、米国の科学ビデオジャーナル「Journal of Visualized Experiments」で一般公開され...
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研究代表者・高橋賢は2018年7月末からアメリカのボストンに渡航し、ハーバード大学Wyss Instituteで研究を開始しました。当初の計画では2019年7月末に共同研究を終了して帰国する予定でした。しかし、Wyss Institute内で製薬企業などとの連携が強固な「血液脳関門チーム」に...
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Ken Takahashi received the Outstanding Research Award at the 2019 International Conference for Leading and Young Medical Scientists (IC-LYMS 2019) in Taipei, Taiwan, which was organized by the Asia Pacific Society for Biology and Medical Sciences. The purpose of the conference was to provide a platform for the exchange and networking between top scientists, emerging young researchers, and students across a wide spectrum of biological and medical sciences. Nineteen presentations and three posters were presented at the conference, which took place four days from 20th to 23rd December 2019. Takahashi gave a keynote lecture entitled “Ischemia–reperfusion injury” in this small, but exciting meeting. Experts from various fields, including clinical pediatrics…
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Dr. Chen Wang, Ph.D. student in Takahashi lab, won the 1st prize in the poster presentation at the 2019 International Conference for Leading and Young Medical Scientists (IC-LYMS 2019) held by the Asia Pacific Society for Biology and Medical Sciences in Taipei. She presented a poster presentation entitled “Roles of the TRPM4 channel in mitochondrial function, ROS generation, and calcium release in myocardial ischemia–reperfusion injury”. This study was supported by the Fund for the Promotion of Joint International Research (Fostering Joint International Research), 17KK0168. Related: Outstanding Research Award in IC-LYMS2019 in Taipei * * * Takahashi Lab at Okayama University uses principles of physiology, cellular and molecular biology, and biophysics. The purpose…
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Toward the development of individual model of ischemic heart disease Heart attack caused by ischemia is a major medical problem that threatens our healthy life. Researchers at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences developed a model of myocardial infarction using cardiomyocytes differentiated from human induced pluripotent stem cells. The journal Biochemical and Biophysical Research Communications published the study, with Ken Takahashi, Ph.D., as corresponding author, and Wei Heng, MSc., a graduate student in the Naruse Lab, as first author. To date, laboratory animals such as mouse have been used to model diseases including myocardial infarction. However, there have been concerns about difference in characteristics of cardiomyocytes e.g. heart…
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Heart cells sense that they are stretched when the heart is subjected to high blood pressure. But how? It is known that concentration of calcium ion in cardiomyocytes increases when they are stretched. Takahashi and co-workers found that a specific protein, L-type calcium channel, is the key to this calcium increase event using rat cardiomyocytes. The article “L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2” was published in Cell Calcium journal. https://doi.org/10.1016/j.ceca.2019.02.008 As the L-type calcium channels are one of the fundamental components of cardiomyocytes involved in beating of the heart, every medical student learns about them. If you have high blood pressure, you might be taking…
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Ken Takahashi gave an oral presentation titled “Simultaneous mapping of multiple proteins in heart using matrix-assisted laser desorption/ionization imaging mass spectrometry” at the European Society of Cardiology Congress 2017 on August 26, 2017 in Barcelona, Spain. He enjoyed the “rapid fire abstract” session, in which a presenter was given only 5 minutes, the beautiful city of Barcelona, and delicious cuisines. The abstract is published in European Heart Journal, Volume 38, Issue suppl_1, 1 August 2017, ehx501.45, https://doi.org/10.1093/eurheartj/ehx501.45 This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (C), number: 16K01356. Related: Heart attack modeled with human stem cells * * * Takahashi Lab at Okayama University uses principles of physiology, cellular and…
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